The parent is asking about how bun compare to Deno, not node. TSC, tsx, and ts-node are nodejs related. I also would like to know. Deno seems to be mature and ready. It runs .ts files from command line. Of course there is no point of picking one JS runtime over another. I would follow the WinterCG group, and use something that is runtime agonistic like hono. It already has a React like front end built in (jsx-lite type).