CUDA was released to consumers in 2006. AMD had plenty of time to counteract that with their own well before the AI boom, especially since back then they now had both CPUs and GPUs under the same roof meaning they actually had an advantage on paper over Nvidia at the time.

It was even their initiative back then called Fusion, and because of that I though AMD would end up overtaking both Intel who could only do CPUs and Nvidia who could only do GPUs. Instead their APUs turned out to be just mediocre CPUs and GPUs at beast without ani killer apps/features, and so lost both markets and had to struggle to regain at least the CPU sector but mostly because Intel was complacent and incompetent on the architecture and manufacturing sides.

Also what does "oppty" from the title mean?