If you've ever worked on a project with a 40 minute build (me) you can appreciate a language like go that puts compilation speed ahead of everything else. Lately I've been blown away by the "uv" package manager for Python which not only seems to be the first correct one but is also so fast I can be left wondering if it really did anything.
On the other hand, there's a less popular argument that the focus on speed is a reason why we can't have nice things and, for people working on smaller systems, languages should be focused on other affordances so we have things like
One area I've thought about a lot is the design of parsers: for instance there is a drumbeat you hear about Lisp being "homoiconic" but if you had composable parsers and your language exposed its own parser, and if every parser also worked as an unparser, you could do magical metaprogramming with ease similar to LISP. Python almost went there with PEG but stopped short of it being a real revolution because of... speed.
As for the kind of problem he's worried about (algorithms that don't scale) one answer is compilation units and careful caching.