I think this is a vast oversimplification of how knowledge works. Like yes, no one knows with perfect certainty what the laws of physics or whatever else are, but that hardly means _anything_ is plausible or worth entertaining.
I amuse myself with the foundations of physics and I'm so sure that FTL is impossible that I find science fiction that uses the idea almost tragically silly, simply unwilling to grapple with the limitations imposed on us by the vastness of space.