You just need a wsgi.py file:

    import os
    import django
    from django.core.wsgi import get_wsgi_application
    os.environ.setdefault('DJANGO_SETTINGS_MODULE', 'mysite.wsgi')
    application = get_wsgi_application()

    ROOT_URLCONF = 'mysite.wsgi'
    SECRET_KEY = 'hello'

    def index(request):
        return django.http.HttpResponse('This is the homepage')

    def cats(request):
        return django.http.HttpResponse('This is the cats page')

    urlpatterns = [
        django.urls.path('', index),
        django.urls.path('cats', cats),
    ]

Put that file in /var/www/mysite/mysite/wsgi.py, point your webserver to that file and you are good to go. In Apache you do it like this:

    ServerName mysite.local
    WSGIPythonPath /var/www/mysite
    <VirtualHost *:80>
        WSGIScriptAlias / /var/www/mysite/mysite/wsgi.py
        <Directory /var/www/mysite/mysite>
            <Files wsgi.py>
                Require all granted
            </Files>
        </Directory>
    </VirtualHost>

https://coltrane.readthedocs.io/en/latest/#other-minimal-dja... has a list of a few options, but the most recent is https://github.com/pauloxnet/uDjango.