Flameshot has key bindings just like any other screenshot program. If the shortcut is already bound by another program, then it will not let you bind it to Flameshot, I believe.
I have been using Flameshot portable for years and it isn't without missing features but I keep coming back to it. I generally use the copy function, sometimes save to location. It would be good to have a built in editor that can be loaded after the action.