Nintendo Switch modchip - PicoFly: https://github.com/rehius/usk. That is the OG source of the firmware behind the already mentioned https://github.com/Ansem-SoD/Picofly
OG XBox Modchip - Modxo: https://github.com/shalxmva/modxo (see initial impressions from ModzvilleUSA at https://www.youtube.com/watch?v=uUsov3i6jL0)
XBox360 NAND reader / writer - Picoflasher: https://github.com/X360Tools/PicoFlasher (used in the RGH3 hack for some versions of the console as described at https://consolemods.org/wiki/Xbox_360:RGH/RGH3)
Gamecube Modchip - Picoboot: https://github.com/webhdx/PicoBoot
Gamecube Optical Drive Emulator - Flippydrive: https://github.com/OffBroadway/flippydrive as described at https://teamoffbroadway.com/
The RP2040 real advantage its name, its price and its availability during the pandemic chips shortage. It lacks peripherals and it's power consumption is awful.
For me, the existence of a MCU/MPU with better features at better price is irrelevant if I can't get known parts on small form factor eval boards using top links on google. Yes, I'm that lazy, but we live in a world with an embarrassment of really good options compared to 20 years ago.
Normally, I can also test a domain-specific subcircuit or two in my "EVM" as well with no added design risk.
That's why you'd choose RP2040.
Yeah, would love these on RP2040.
As well as better ADC, "halved" (half mem, IO, PIO and CPU) cheaper version, "doubled" version (2x mem, IO, PIO and M4f CPU cores), integrated flash version, etc. Better power consumption.
That said, I do like PIO and you can use RP2040 as a PIO-peripheral to something more protected.
https://github.com/polpo/picogus
Emulates all kinds of sound cards, including the Gravis Ultrasound.
https://github.com/FreddyVRetro/ISA-PicoMEM
Emulates a memory extension, but also so much more stuff.
E.g. see https://github.com/Ansem-SoD/Picofly.