Support of Israel goes back to JFK.
It used to be strategically important during the cold war when the US and the Soviet Union were fighting for influence. Egypt and Syria e.g. were aligned with the soviets. Israel as one example, was testing ground for western weapons against soviet weapons. The US got a lot of information out of Israel about those weapons and how to defeat them.
Weapon technology is still something important today. Israel and the US collaborate on anti-missile systems and share the testing results those systems are getting in the field. That's just one example. Americans follow Israel's tunnel fighting tactics as well. Israel has always had more human intelligence in the area and also shares that with the US.
The middle east is still important today. I guess there's oil. And as we can see shipping. Saudi Arabia that used to align with American interests has been looking in other places, has always been a somewhat questionably ally, and the stability of its regime is always a question. Egypt has been sort trending a little back to Russia but for the time being put in place. It's also not the stablest place given the Muslim Brotherhood had control and the army took over. Turkey is also becoming less US oriented. And that's practically Europe.
The US under Obama has tried to reduce its involvement in the region which indirectly led to the civil war in Syria, to Iraq aligning with Iran, and other movements. Bin Laden was from the region and so is/was ISIS/ISIL. It feels like the US "disconnecting" from the region would be a destabilizing move felt everywhere and other parties like China or Russia would fill in the vacuum.