Comment by Spod_Gaju | Hacker News Reader

Comment by Spod_Gaju | Hacker News Reader

I am the OP. First, I am glad this post has gotten so much attention and traction.

But what if I told you I cured my mental illness at 58 years old, a serious case of Bipolar Disorder Schizoaffective Type that had me on Disability and in and out of psychiatric hospitals since I was in my early 30's?

What if I told you it was more than holistic but it was holistic thinking that helped me cure my disorder.

Will you all listen to me or write me off by saying that nothing I say is true because I had a mental illness? Will you be like my doctors who do not believe I am better? That I have no more mental illness along with all the neurological issues that came with it?

And what if I told you what I have discovered in myself can be applied not only to mental illness but to everything from Cancer to Alzheimer's to ME/CFS and Long COVID?

If there is one person here who will take the time and have a creative mind to understand what I am saying I will explain it?

Doesn't bipolar often get better by itself after 50? That happened to family members and they certainly weren't trying to improve their lifestyle.

=^|

No. I do not want to say never, but without intervention it is rare.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226928/

Please expand :)

My disorder was caused by too much ATP in the mitochondria and too little in the cytosol. I have a Partial PNP Deficiency[1].

The higher ATP and GTP in my mitochondria causes higher sensitivity to all the G Protein Coupled Receptors[2], this includes the serotonin and dopamine receptors. So any increases in serotonin was exaggerated leading to psychosis and delusions much like someone would have on psilocybin.

This was cured by a low calorie, high seafood diet, a lot of walking, and limiting exposure to oxidative stressors like air pollution.

Most people however have the opposite problem; too little ATP in the mitochondria and too much in the cytosol. This leads to low energy receptor function. So when that person is exposed to dopamine there is very little reaction so they keep seeking dopamine. Hence we have depression and addiction.

In short, changes in the Purinergic pathway cause mood disorders. And this is not even a radical statement, it is just not well known[3].

So you can see why things like SSRIs will work, but stop working after a while. Since nothing is being done to correct the low mitochondrial ATP.

Comments so far?

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338719/ [2] https://www.guidetopharmacology.org/GRAC/ReceptorFamiliesFor... [3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262688/

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