1. For one there’s the perchlorates. Basically the dust is poison.
2. After that, there’s pressure or I suppose the lack there of basically You might as well be in space.
3. Solar panels don’t work for shit on Mars, because it’s so much further away in the inverse square law is a bastard.
4. It’s a long ass way away.
5. The lower gravity has implications long term for having babies.
Like, I think we should explore space, and become a multi planetary species, but I don’t know that Mars is the place for a viable long-term colony. I’m much more partial to Venus-cloud-cities or something similar.