I imagine the drug atenolol would become popular among politicians.
With public figures, however, if you collect enough video of various activities, you could determine a baseline physical demeanor. Then, if the figure in question radically steps out of that baseline, you can send off red flags.
Ideally, this could be used to analyze facial dynamics to help determine focus, expression (for example, the SOEmote video that was recently posted), mood (though we now get back into personality traits), or, as the video showed, subtle changes in the physical body.
This is exactly the kind of amplification you need. Something like the movement caused by mirror of an SLR camera (at the end of their demo) is very very short in duration, but they amplify the magnitude AND slow the video to allow it to be visible.
Politicians in front of cameras are too heavily covered in face powder for their real color to shine through.
Of course, use of those techniques will themselves come to indicate guilt...
I wouldn't make assumptions. There's a valid point in wanting to defend your thoughts and intentions.
It could be interesting to look over old films of riots to see how they may have been instigated...
The technology is probably not mature enough for video analysis, though.
Does it work on cold-blooded animals too?