If these things are unpredictable it’s likely because they simply haven’t been studied in a medical context. At the very least it’s reasonably clear that long-term and debilitating side effects are generally exceedingly rare.
More people than you probably expect die from tylenol.
Getting out of depression or other severe conditions is hard, whether using psychedelics or SSRI. Take care of yourself so you don't get there in the first place.
Sorry but this is a very ignorant perspective in my opinion. Psychedelics are wildly ubpredictable in their effects, even those that have been extensively studied, like LSD. You cannot predict how an individual will respond.
This is also true of many prescription meds.