I think it all depends on the language, but I found it (usually) easier to implement the recursive-descending parsers just manually. This may include combination approach too, but using my own combinatorial and domain-specific functions.

In a nutshell such a parser is PEG in a sense that the choice is ordered, but with little to no test expressions. In other words, I try to stick to lookahead-1 most of the time. Left recursion quite often could be resolved by lifting the branches to their siblings rather than re-parsing the same things many times using the cache (packrat). In fact both approaches, the packrat and the nodes lifting, are the same in a nutshell, but nodes lifting is usually easier to maintain (again, it all depends).

Writing the parser manually, or in other words a set of relatively simple mutually recursive functions, in my opinion, is not the hardest problem in practical engineering. At least it's not so hard when you have a mental model of the language's syntax upfront.

If the language fits specific class of formal grammars very well, perhaps it would be not so hard to implement it using the parsers generator tool. But it is likely there will be edge cases that are hard to express properly using the formal grammar, and fighting with the tool specifics will waste a lot of your time rather than benefit you.