It's not just that the weight is gained back but the rate that it's gained back. Imagine someone loosing 100 pounds on semaglutide and then gaining 70 pounds of it back in 1 year when they stop taking it. That's over 1 pound a week of weight gain, likely much faster than that individual gained the 100 pounds originally. That type of rapid weight gain is associated with even worse health effects than carrying the extra 100 pounds probably was, and that's just at 1 year, where will this individual be in 2 years, 3 years etc? Will they really keep that other 30% weight off? We don't have the data yet, but it doesn't seem likely they will. I'm not saying we shouldn't use these drugs, just that we need to understand that they are only the first step to a much longer strategy to improved health.