I grew up in the US in a low-sugar household and when I became an adult I found a lot of restaurant food and pre-packaged meals to be strongly, unpleasantly sweet. I heard the same thing from foreign students when I went to graduate school: American food is too sweet. It's not "indulgent" but actually unpleasant. I presume that it's possible to reset your default sweetness expectation to a higher level, since it's happened on such a large scale, but I never did. If these drugs can perform a palate reset for sweetness, people could remove a lot of empty calories from their meals.