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You need an analogue of Linux distributions (Python distribution? Making choosing a repo a separate and deliberate step?).

That way you could pick a repo based on your risk appetite rather than needing to trust PyPI. Debian style python for the cautious and AUR style python for the bleeding edge and reckless.

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Isn't that just already my linux dist, if I want to?

I can install python-matplotlib from my package manager, and it appears in my python path. I never bother with venvs.

Maybe my needs aren't advanced (or exotic) enough.

Not really - just downloading files and storing them on the filesystem would be good enough. No need to run an arbitrary setup.py script.

But setup.py is part of the Python's legacy, from before PyPI even existed.

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