Difficult, but not impossible… I’ve also used roundabouts over highway traffic, but not with the same throughput of traffic that interstates have.
They aren't really in competition with each other under most circumstances. It's like comparing bicycles and trains for transportation.
East can only enter the roundabout when there's a gap, and if the south to north traffic is coming from an event, or a roro ferry, it's going to a lot of waiting. A traffic signal that's in event mode isn't going to give the east entrance much time either, but it will have some limit, most likely before the capacity of the ferry or the ballgame parking lot.
See here for e.g. for a large one that intersects several major roads: https://maps.app.goo.gl/51sQeVa4ozSQgW9U6?g_st=ic