Boxee would really be a cool app for it. Also, we thought about a TV-guide application on the frame as well, so it could be a companion to your TV.
How about an alarm clock? There's more people who use alarm clocks than have twitter accounts. Add your existing weather app, so I can see what to wear in the morning.
Also a simple Facebook feed? Using the Python API you can do this in a few minutes, give me a buzz if you want me to paste example code.