I can agree on this line, but I would try to get my hands on some serious information and speak with one or more doctors.

I thought it wouldn’t end well for the “rich” people - they would end up with some consequences like man-bear-pig or participating in fads like Prime energy drink.

But it wasn’t great either. Cartman never got thin, randy never got thin, women got abs - and maybe super high cravings/addiction to the drug.

That got me thinking, are they saying that this drug is legit but expensive because of the messed up healthcare system or its just a rick people fad and get them to do stupid things.

It was by far one of their most unrelatable escapades. The commentary on the US healthcare system was good, but everything else just felt like Hollywood problems. I think Matt and Trey no longer inhabit the same space as everyone else, and it's showing.

(Other comments: the character interactions felt wrong, Kyle was too willing to help Cartman, and Butters was too willing to help without being cajoled into it first, the shootout scene felt clunky and even gratuitous. It felt very low effort towards the end.)