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In my experience this seems to be true. For a while it seemed throw away emails were pointless to try and they would all be blocked. But over the past couple years I’ve had a lot of success using mailinator, which is probably one of the better known services which has been around for a long time.

I don't think sites have problem with alias emails like iCloud Hide My Email. The issue is when they are used for creating spam accounts.

They could end in @privaterelay.appleid.com which is... easy to block.

Only those emails generated by Sign In With Apple AFAIK

Do any HN commenters here know of any maintained lists of throwaway email domains?