Plutonium-328 is a trace impurity in general plutonium production, but production of RTG-grade Plutonium-328 needs to be done in special reactors, where Neptunium-237 is bombarded with neutrons. The US shut down its only Pu-238 producing reactor in 1988, along with the rest of the Savannah River Site. Since then, Russia has been the sole source of Pu-238. Since 2013 the US has been trying to set up a new Pu-238 production plant at Oak Ridge National Labs, but even at full scale production it can still only produce 1.5 kg per year.
> nuclear powered pacemakers
?!?!
Thank you for a bit of shocking weirdness I had no idea about. Good article: http://large.stanford.edu/courses/2015/ph241/degraw2/
The United States started making Pu-238 in useful quantities again last year:
https://www.ornl.gov/news/pu-238-shipment-quantity-opens-tap...
https://www.energy.gov/ne/articles/us-department-energy-comp...
The process requires irradiating neptunium-237 (itself a small portion of spent nuclear fuel, requiring special chemical separation) in a government reactor.
It's also true that Pu-238 is dangerously radiotoxic if inhaled or ingested, but that's true of every material that provides a useful quantity of decay heat, including the americium-241 alternative used in this new mission.
The primary advantage of using Am-241 over Pu-238 is that it's easier to recover from spent power reactor fuel; there's more of it in spent fuel than Pu-238, and it's the most abundant isotope:
https://en.wikipedia.org/wiki/Isotopes_of_americium
Which means that Am-241 can be separated chemically from old fuel and does not require any additional nuclear treatment before use as a radioactive heat source.
https://bellona.org/news/nuclear-issues/radioactive-waste-an...
Strontium-90 decays by beta emission, ending up as stable zirconium, meaning you don't have to vent helium.