I don't think that's true. The video in the post shows a no-name n64 game being recompiled and running fine. No annotation needed.
Also, after conversion these games are still designed and hardcoded for an N64 controller and 4:3 aspect-ratio - that’s hardly “native” as far as PC gamers are concerned.
[1] https://ultra64.ca/files/documentation/online-manuals/man/pr...