if you want a protien or any other bio molecule to fold properly, a chaperone system must be either designed or elucidated.

the primary sequence is not the only consideration for proper folding.

chaperones allow higher energy folding events to occur and be maintained until subsequent modification stabilizes high energy structural motif.

chaperones also enforce an A before B before C regime of folding so that the sequence doesnt just crumple up according to energy of hydrostatic interactions