The most obvious comparison is in syntax. Easier syntax means less user time spent. In Symbolica, an example from the documentation

    from symbolica import Expression
    x = Expression.var('x')
    f = Expression.fun('f')
    e = x + f(x) + 5
    e = e.replace_all(x, 6)
    print(e)

In Mathematica, the same thing is

    e = x + f[x] + 5
    e /. x -> 6

What I find striking is that, we know that Python is the most popular language because you don't have to declare your variables or your function headers, and can just start writing the logic of your computation. Then, people keep inventing these mathematics programs in Python, that need you to declare your variables before using them.