Although I've been working with django daily for about the past six months, I used bottle for a small stand-alone 'desktop-like' application.

I needed an easy, quick way to take roll call of a large group of people. We have a laptop with a projector but no internet access where the meeting occurs, so it had to be able to live on a Windows machine without network access. Bottle allowed me to pull together something in about five hours that uses sqlite for local storage of all of the participants names and whether they are present/absent and any notes. Previously, I was doing this on an inherited excel spreadsheet and it was very difficult for anyone else to read their name or any information. Now, it's a very simple HTML page with very large font that can be read from the back of the room.

So, thank you bottle! I was able to develop on Linux and fairly painlessly deploy it to the Windows laptop, and it worked the first time. (That was scary... Rarely happens to me.)