Yes. I regularly use F2 and F3. F1 help I cannot remember the last time I used it. I also get irritated by windows applications that do not use F3 for find next. I do not use F4 without a control or alt combo though...
And over the years, I've had several keyboard where I've physically removed the F1 key from keyboards used on Windows machines because of how annoying the experience was if you ever accidentally pressed F1.