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> ISPs often deprioritize traffic from S3

I wonder why

You should never be serving content from S3 directly anyway. Always setup a cloudfront distribution for your buckets and allow origin access identity (OAI) access to the bucket.

Also a good idea to stream large files instead of trying to directly serve the file as-is. For video you essentially have to stream the file in order for it to load on Safari.

Cloudfront does not solve it. Comcast deprioritizes any content that comes from Amazon.

Not to mention using Cloudfront in front of S3 can lower cost, due to caching.