I haven't kept up on the current state of cheats, but 10 years ago there were cheats that would automatically last hit minions (necessary to gain gold), automatically path towards your cursor while aiming and targeting your skills, move you out of the way of incoming abilities, all with inhuman reaction times.

There was a motto through the LoL cheating community of "Spacebar to Win", where spacebar was the keybind for unloading all your abilities and trying to kill the opponent. A player with good game knowledge and game sense would be easily able to climb to Challenger (the highest rank bracket).

There was a bot that played as a support champion and with a basic decision tree it reached Silver 2. Someone wrote a neural net algorithm for it instead and it reached Gold 4.

Probably eliminate fog of war.