I think the main benefit with this approach is expected-behaviour (like how different desktop operating systems have different textbox behaviour), and that whatever accessibility you get by default with native controls is there. [1]
I don't really find their approach to GUI development compelling though, with them choosing a middle ground between "wrapper around native controls" and "implement everything yourself".
[0] Except on Linux and web, where Uno draws everything itself, imitating controls that look like GTK (on Linux) or UWP/WinUI (on web). These are the platforms I briefly tested on and I didn't have an enjoyable experience with the output due to non-native/non-expected behaviours.
[1] Page on accessibility: https://platform.uno/docs/articles/features/working-with-acc...