From a psychological perspective there are only three modes to explain chronic anxiety (in order of severity): brain lesions impacting the amygdala, a combination of damage to various other brain circuits with a similar result, or poor adversity conditioning during childhood.

For persons with actual brain damage anti-anxiety medications are necessary and in extreme conditions prevent catastrophic autonomic organ failure for organs managed by the brain. In many cases anti-anxiety medications are over prescribed to people with minor emotion coping disorders.