Yes, I made a game that you controlled by whistling, back in 2018 with the WebAudio API.

My version of the cursor kept a continuous scan velocity horizontally across the screen, and you controlled the y-axis via pitch. Button presses were (intentional) collisions.

I made a game like this the other day just for fun! It worked pretty well but it's more of a novelty and not really fun to whistle for more than 30s.

Or even talk to your computer https://en.wikipedia.org/wiki/Whistled_language