MacOS is notorious for this. By default, it would only run binaries signed with an Apple-issued certificate. You can bypass this multiple different ways, of course, but that requires knowing that it can be bypassed in the first place.

Then there are mobile OSes where you don't get to see the binaries at all. Yes you can repack an apk but again, that's a more involved process requiring specific tools and knowledge (and very awkward to do on the device itself), and iOS is completely locked down.