I'm recently back on macOS for work, and I wanted to love nix-darwin, but just couldn't get it even installed / basics running well enough to start to enjoy configuring things with it. The whole flakes mess really doesn't help.
(Maybe if you're already running NixOS and familiar with the latest it's a lot easier.)
I couldn't even uninstall it cleanly, since the Mac was new I gave up after some time and decided it was easier to reinstall macOS (which takes several hours but at least I can just leave it and then know that it's done).
So I'm back to (purely) brew (and scripts to `defaults write` etc.).
My frustration with brew is that it's getting increasingly opinionated, and those opinions are not familiar to me from any other OS/package manager... Like if you want postgres v15 you have to `brew install postgresql@15`, and then even if that's your only installed version it's 'keg-only', which means it's not on your PATH, and their suggestion is to dump some stuff at the end of your ~/.zshrc, which aside from the fact you're not using zsh and they could tell that, just seems dumb.
Then there's python & npm packages... They're deprecated and being removed as independent formulae, so don't do it like that. You're not allowed to install them with the python/node formula you installed, so don't do that. So what do you do, `python -m venv ~/system-python-venv` or something, activate it, and install in there. And now remember to activate that every time you want to use a command that happens to be a python package so you had to install it there. Or dump it in the end of your zshrc, I guess!