Before position and float madness and all, we used to abuse tables -- because layouts for complex information do work best in grid systems. Now CSS finally has a module that serves this purpose, and brings a huge amount of flexibility to make formerly painful stuff easy.
I'm not even talking about "page layouts" as a whole, just simple particle patterns like "a big icon with a title + description to it's right" is so so much cleaner and easier to do in markup AND css with grid.
Embrace the tools, and if you dislike them - you may as well just not use them. But thinks like grid make simple, stupid, deadlined webdesign _work_ so so much less of a grind.
(speaking as a General Graphic Designer who's also been deep, deep in CSS since before 2.1)