note that i'm not claiming 2x slowdown for cpython.

but here's one test i've run just now:

using your test file, i've run this one-liner on my x86_64 linux laptop in https://pyodide.org/en/stable/console.html in chromium (v8) and natively (pyodide's urllib doesn't handle https for some reason):

   import requests;exec(requests.get('https://gist.githubusercontent.com/syrusakbary/b318c97aaa8de6e8040fdd5d3995cb7c/raw/1c6cc96cf98bd7bd41c81ba9d10dc4d19b1c3e53/pystone.py').text)

native: ~470k

pyodide: ~200k

i.e. ~2.4x slowdown