You mean simulate billions artificial neurons, right?
You can't simulate a single biological neuron yet because it's way too complex and they still don't even understand all of the details.
If they did have all of the details, at minimum you would need to simulate the concentrations of ions internally and externally as well as the electrical field around the neuron to truly simulate the dynamic nature of a neuron in space and time. It's response to stimulus is dependent on all of that and more.