The Add-on allows you to enable or disable specific domains serving JavaScript, and automatically save those preferences for later visits. I find that I only notice the add-on for a few days on a new device before it is tuned. After that, the only thing I notice is how slow and garbage-laden the same sites are when I'm on a computer without my setup using e.g. Chrome
YMMV but I have been NoScript-ing for 2 years and won't go back by choice.