Thoughts on Seed Oil
dynomight.substack.com
dynomight.substack.com
Which do you think is worse: smoking, or seed oils?
Which do you think is worse: smoking, or not exercising?
https://jamanetwork.com/journals/jamanetworkopen/fullarticle...
Look at Figure 2C in particular. The hazard ratio of smoking is 1.41. The hazard ratio between "Low" (<25th percentile) and "Below Average" (25th-49th percentile) cardiovascular health is 1.95.
In other words, it is better to be a smoker than in the lower 25% of non-exercisers. By far. It's not even close.
Seed oils are 100% a distraction. Once you're in the upper 2.3% of vo2max for your age/sex, _then_ you have the right to worry about seed oils. Until then, save your energy for interval training.
Minor in the minors, major in the majors.
I’ve never been a cigarette smoker but enjoy a cigar a few times (2-3) a week in the summer (4 months or so out of the year). Obviously not smoking is better, but I’d like to have hard data what kind of risk I’m taking.
Ex: is the risk similar to two drinks a day, is the risk similar to enjoying a bonfire or is it similar to an entire pack of cigarettes.
Edit: Table 1 might have our answers https://cancercontrol.cancer.gov/sites/default/files/2020-08...
Here's one study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755640/
https://academic.oup.com/jnci/article/91/8/697/2519397
https://bmcpublichealth.biomedcentral.com/articles/10.1186/s...
https://pubmed.ncbi.nlm.nih.gov/24457405/
https://harmreductionjournal.biomedcentral.com/articles/10.1...
Seed-oil harm is nowhere close to the second-highest hazard. That's the point. If you're obsessing around optimising your oil consumption for health, you're probably missing lower-hanging fruit. It's fine to optimise on around the margins, but any more attention than that--assuming you are not a researcher--is overkill.
Sure exercise is a overall bigger impact, but adjusted for effort, eliminating seed oils is likey a higher effort/value proposition, and that means that at scale, more people are likely to follow through
The article argues that the median increase in BMI over time was 0.05kg/m^2/yr. The prevalence of smoking starting in the 80s dropped from 60% to 10%. So smoking rate is going to account for a non-trivial amount of the increased median BMI. In fact, the rate of obesity really started skyrocketing in 1980 which is right when we hit peak cigarette in the US.
If it's true as you say that it's better to be a smoker now than a non-smoker -- it's only because you're going to lose weight, and that's your biggest risk factor for all-cause mortality.
Makes sense when you consider bupropion, a nicotinic receptor antagonist, shows statistically significant weight loss (clinically signifiant when combined with naltrexone). It’s like 60% of the population was on bupropion.
If it’s just to lose weight then you’re probably better off with ozempic than a pack of American Spirits.
Also I dislike the article's use of BMI over very long timescales, going back to the 1800s. BMI is fine for most people these days (because most people have a lot of weight on them, see the article) but a lot of the 1800s BMI gain was probably just due to better nutrition not higher fat percentages. Over long time horizons we probably want to measure waist-to-height ratio or body fat percentages. The 1890s BMI delta was probably all lean mass, and good-to-neutral whereas the 1990s BMI delta was probably all fat mass and overwhelmingly bad. I’d argue that probably continued until 1940 where the thinnest 10% begin to remain constant, having their basic nutrition needs saturated.
tl;dr: it's almost certainly not seed oils — and maybe not smoking is making us fat? I’m gonna look for a trend a write up a blog post haha.
the negative health effects of smoking negates the weight loss . despite being slimmer, smokers die 10 years earlier compared to the general population. obese people only lose a few years (1-3 years for moderately obese men).
As for smoking being less bad than not exercising, citation needed. Did you read the article linked by @AlexErrant above?
> Look, I wish strong seed oil theory were true. That would be great. All we’d have to do is reformulate our Cheetos with different oil, and then we could go on merrily eating Cheetos.
The problem with our (Western) diet isn’t that we’re using seed oil. It’s the diet itself.
The author seems to suggest that it’s all the same because “of course fries are junk food” but there is a significant health difference if you recognize that reusing seed oils at high frying temps over and over again degrades the oil in a way that is not the same as with saturated fats.
That is going to create a lot of oxidative stress and inflammation.
Can you define "a lot" in this context?
On top of that, it's all genetics and pointless to worry about. Just enjoy the ride. BD
You are operating under the assumption that raising cholesterol levels is somehow a terrible thing.
I resisted for a long time but I'm finally swayed and am medicating to take the ApoB levels down (diet and exercise can help but medication seems to be the strongest factor).
"An overwhelming body of multiple, converging lines of evidence has established a causal role for LDL in atherosclerosis and CHD/CVD progression as a fact, beyond a hypothesis."
https://sigmanutrition.com/lipids/ has a very good overall survey of the field.
“Cholesterol is not considered a nutrient of concern for overconsumption.”
https://www.health.harvard.edu/blog/panel-suggests-stop-warn...
"An overwhelming body of multiple, converging lines of evidence has established a causal role for LDL in atherosclerosis and CHD/CVD progression as a fact, beyond a hypothesis."
https://sigmanutrition.com/lipids/ has a very good overall survey of the field.
then again maybe its cause those taste the best due to being evolutationary selected and companies arent trying to kill us but get us to buy whatever our bodies easily go for.
There are some recyclers now that will pay you a bit for used oil, but I doubt it's enough to make it cheaper to buy fresh vegetable oil rather than cooking the fries in the beef fat you already have.
I really wish there was a magic bullet to the obesity epidemic. An ingredient we can just stop using, or a diet that will fix all our problems - but that's just not realistic. The evidence points to this being a messy multivariate problem that extends beyond just diet to things like lifestyle, poverty, and cultural norms.
It's so much easier to believe that "with this one trick" we can fix everything but when has that ever worked? Thanks to the author for writing this up.
If you want to wait for conclusive evidence when all of the studies are financed by the companies that earn revenue from processed seed oil, be my guest.
http://www.ncbi.nlm.nih.gov/pubmed/3921234
Requirement of essential fatty acid for mammary tumorigenesis in the rat. http://cancerres.aacrjournals.org/content/4/3/153.full.pdf
However, when the corn oil was replaced by hydrogenated coconut oil the tumor incidence never exceeded 8 percent, while in most groups it was zero. https://pdfs.semanticscholar.org/b44f/0f82cbb7d9473ac99c3866...
Thus the substitution of hydrogenated coconut oil for corn oil definitely inhibited tumor induction... https://www.ncbi.nlm.nih.gov/pubmed/6704963
These findings suggest that dietary unsaturated fats have potent cocarcinogenic effects on colon carcinogenesis. http://www.ncbi.nlm.nih.gov/pubmed/6815624
Inhibitory effect of a fat-free diet on mammary carcinogenesis in rats. https://link.springer.com/article/10.1007/BF02531379
Experiments with 10 different fats and oils fed at the 20% level indicated that unsaturated fats enhance the yield of adenocarcinomas more than saturated fats. https://www.ncbi.nlm.nih.gov/pubmed/7285004
Thus, diets high in unsaturated fat appear to promote pancreatic carcinogenesis in the azaserine-treated rat while a diet high in saturated fat failed to show a similar degree of enhancement of pancreatic carcinogenesis. https://www.ncbi.nlm.nih.gov/pubmed/6577233
...tumors grew to a larger size in C3H mice fed the 10% corn oil diet...than in those fed the 10% hydrogenated oil diet (without linoleate). The C3H mice fed diets with 1% linoleic acid developed significantly larger tumors than did those fed 1% oleic acid... https://www.ncbi.nlm.nih.gov/pubmed/6587159
...corn oil (CO) diet, which contains linoleate...hydrogenated cottonseed oil (HCTO), a diet free of the polyunsaturated fatty acid...Both incidence and growth rate of tumors...were greater in mice fed diets containing either 0.3, 1, or 10% CO than in those fed 10% HCTO. https://www.ncbi.nlm.nih.gov/pubmed/1255775
...mammary tumor growth was depressed by a fat-free or saturated-fat diet and enhanced by dietary linoleate. https://www.ncbi.nlm.nih.gov/pubmed/817101
The cumulative incidence of tumor-bearing rats among DMBA-dosed rats was greater when the polyunsaturated fat diet was fed https://www.ncbi.nlm.nih.gov/pubmed/3459924
...animals fed the HF safflower and corn oil diets exhibited enhanced mammary tumor yields when compared to animals fed HF olive or coconut oil diets... https://www.ncbi.nlm.nih.gov/pubmed/107358
These results show that a certain amount of polyunsaturated fat, as well as a high level of dietary fat, is required to promote mammary carcinogenesis. https://www.ncbi.nlm.nih.gov/pubmed/6782319
...the addition of 3% ethyl linoleate (an ethyl ester of a polyunsaturated fatty acid) increased the tumor yield to about twice that in rats fed either the high-saturated fat diet or a low-fat diet. https://www.ncbi.nlm.nih.gov/pubmed/3476922
...animals fed HF diets rich in linoleic acid, such as safflower and corn oil, exhibited increased incidence and decreased latent period compared with...animals fed HF diets rich in oleic acid (olive oil) or medium-chain saturated fatty acids (coconut oil). https://www.ncbi.nlm.nih.gov/pubmed/416226
The differences in tumor incidence suggest that carcinogenesis was enhanced by the polyunsaturated fat diet during the promotion stage of carcinogenesis. https://www.ncbi.nlm.nih.gov/pubmed/6488161
...they suggest an association between promotion of mammary cancer and elevated levels of linoleic acid in serum lipids. https://www.ncbi.nlm.nih.gov/pubmed/2979798
These results suggest that a diet high in unsaturated fat alone, or in combination with 4% cholestyramine, promotes DMBA-induced mammary cancer in Wistar rats. https://www.ncbi.nlm.nih.gov/pubmed/26091908
Groups of animals fed the corn oil-enriched diet showed the highest percentage of tumor-bearing animals, significantly different in comparison with control and HOO groups. Total number of tumors was increased... https://www.ncbi.nlm.nih.gov/pubmed/6583457
...effect of dietary corn oil (CO), safflower oil (SO), olive oil (OO), coconut oil (CC), and medium-chain triglycerides (MCT)...The incidence of colon tumors was increased in rats fed diets containing high-CO and high-SO...whereas the diets containing high OO, CC, or MCT had no promoting effect on colon tumor incidence. https://www.ncbi.nlm.nih.gov/pubmed/6778606
...an increase in fat intake was accompanied by an increased tumor incidence when corn oil was used in the diets. A high saturated fat ration, on the other hand, was much less effective in this respect. https://www.ncbi.nlm.nih.gov/pubmed/9066676
The promotive tumorigenic effects of the other high-fat diets were associated with their high levels of some polyunsaturated fatty acids... https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1751-1097....
Mice fed 20% saturated fat were almost completely protected from UV tumorigenesis when compared with mice fed 20% polyunsaturated fat. https://www.ncbi.nlm.nih.gov/pubmed/8973605
...the highest tumour [loads] (fed 15% or 20% polyunsaturated fat),... in comparison with the mice bearing smaller tumour loads (fed 0, 5% or 10% polyunsaturated fat). https://www.ncbi.nlm.nih.gov/pubmed/27033117
...we found an inverse association between SF content and tumor burden...at least in male mice; there was a decrease in mortality in mice consuming the highest concentration of SFAs. https://www.ncbi.nlm.nih.gov/pubmed/7214328
Increased tumor incidence and decreased time to tumor were observed when increasing levels of linoleate (18:2)...Increasing levels of stearate were associated with decreased tumor incidence and increased time to tumor. https://www.ncbi.nlm.nih.gov/pubmed/1732055
A positive correlation between level of dietary LA and mammary tumor incidence was observed https://www.ncbi.nlm.nih.gov/pubmed/6064952
Enhancement of mammary carcinogenesis in the high-corn oil diet group is detectable in most of the parameters studied. https://pubmed.ncbi.nlm.nih.gov/8317898/
...increased the tumor number of rats fed corn oil, but not those fed palm oil....
https://davissciencesays.ucdavis.edu/blog/what-does-science-...
The rats will "get cancer" either way. How else would we know whether something has a positive or negative effect on tumor growth?
You might have to search for "transgenic" or other specific terminology to locate what model they used in the study, but they're assuredly not field mice or something you'd find in a pet store.
Here's a sample of a catalog: https://emodels.criver.com/search?term=*&species=Mouse
Now, no one is going to argue that an all-movie-popcorn diet would be healthy, especially with the fake "butter", but realistically how much movie popcorn do people eat?
According to Gallup, the average American goes to the movies about 1.4 times a year. Not enough for the popcorn to have any measurable effect at all, I reckon.
And now I'm hungry for popcorn. Going to make some. :-)
Nothing new, but Citric Acid consumption is skyrocketing in parallel to other more well-recognized commodities involved in the food processing industry:
https://www.imarcgroup.com/global-citric-acid-market
I don't know if flying under the radar makes it more or less of a boogeyman but I'm not a very happy camper with having added citric acid in every meal and snack.
Chemically being "tribasic", citric can absorb up to 3 times the alkalinity per molecule compared to the acetic acid (vinegar) it is often used as a substitute for. That doesn't mean 3x is always the ultimate ratio if all the acidity were to be neutralized either in vitro or in vivo. Even if the same number or molecules were substituted. Remember pH IS NOT acidity. They are just closely related. An excess of citric can be added without lowering the pH as uncomfortably as an excess of acetic, so you would never know without careful multi-endpoint titration vs pH measurement response.
Now there may be some basis in fact underlying a few ultimately bogus phobias, but you should probably be careful what you consume whether as a food, drink, or a more potent concentrated ingredient like purified liquids or even crystallized solids. Everything which can have toxic effects does have a different toxicity profile.
Not surprisingly, there's a song about the boogie man relative to what toxins you consume:
"I was lying in bed late one night
Had my eyes almost closed I was feeling alright
Looked to the East, looked to the West
Yonder come the Boogie Man doin his best"
The root of all evil is pretty out in front. When I was growing up outside of US, everything we cooked was in peanut oil, coconut oil, rice bran oil and cotton seed oil. Obesity was a rare occurrence and so were heart conditions for adults. But all of our food was entirely home made with the exception of the rare cola, chocolates and ice cream for celebrations. Fast forward 30 years, there isn’t a single item in stores that doesn’t have palm oil. Palm oil is the choice of cooking oil in restaurants. And cooking at home has significantly gone down. Obesity and heart diseases are now common. My parents have a much worse health in their 60s than my grandparents did in their 60s. I have a worse health than my parents did at my age despite being more conscious about health and actively working towards it.
Seed oils are not a problem, how much of it we have is a problem.
That's interesting, do you have any source for that? Is that in US?
I know Palm oil is used in food production because it's neutral in taste, easy to process at industrial scale and overall stable in its characteristics.
As a European, using Palm oil as cooking oil sounds crazy because it actually provides no benefit in a kitchen at all...
Edit: Learnt now that it's the most-used oil in Indonesia, as Indonesia is also the largest producer of Palm Oil (64% of global production in 2020). So they likely use it locally because it's available in abundance there...
In 2020, Indonesia and Malaysia accounted for ~84% of all the Palm oil production in the world [1]
[1] https://www.iucn.nl/app/uploads/2022/10/Factsheet-Palm-oil_I...
https://www.indexmundi.com/agriculture/?commodity=palm-oil&g...
But we do have soybean oil and canola that’s more popular.
I do like the sentiment of the article though, very science-positive with a healthy side of skepticism.
Eat real food, avoid processed crap, and you are 99% of the way there.
Like, it lets people afraid of a seemingly scary, industrialized, effeminate, world feel virtuous, contrarian, and protected by tradition. Plus, you get to eat steaks and butter!
(Edit softens it a little, but still. It's on track to break US's own BMI obese line at 30 before long, I think it's sometimes called an epidemic and rightfully so in that sense? If the median person in a country has a problematic characteristic that's crazy isn't it, should be a bigger deal?)
In particular, the vilification of fat and shift away from meats and dairy has changed the way we eat in the last couple of generations. More packaged food, less ability to perform moderate complexity cooking tasks, etc.
By avoiding seed oils, you tend to eat more whole foods. It's not an awful cue to pay attention to.
not sure how your comment jives with that at all
the health effects of eating seed oil go way beyond obesity. that isn't the only thing anyone who discusses the negative health effects is talking about.
The question I still have is: is olive oil healthier than seed oils (which aren't really that bad based on current evidence)?
No, this can't be true, since HN has repeatedly told me that the body preferentially stores sugar as fat (presumably via de novo lipogenesis, which studies like [1] show to be only a minor contributor to fat balance, but that's probably just more Big Sugar propaganda, right?), that dietary fat doesn't become body fat, and even that you can eat all the fat you want without getting fat because ketones are magic.
1) https://ajcn.nutrition.org/article/S0002-9165(23)06404-3/ful...
I may have read theories that it contributes more to visceral fat, which is really bad for your health? But that won’t be the majority of weight gained I think.
Feels to me like you’re arguing against a pretty big straw man.
Yeah, about that: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171936/
But then I remembered how frothy everyone here was about Soylent when that stuff came out
I say this as an armchair theorist myself, who sticks to olive oil and butter and suspect seed oil is problematic, I'm just not very confident about it. The one nugget of wisdom this article highlights is worth repeating: stick to a variety of natural unprocessed (or minimally processed) foods as much as possible, make it the main part of your diet. For two reasons:
1. Nutrition is a very poorly understood subject, with a history of bad science, we basically know shit about nutrition as a society. For the most part, you Grandma is more likely to give you good advice about healthy eating than most government advice based on bad studies... It's getting better though, there are some decent folks out there trying to understand nutrition properly. And therefore anything we do to adulterate food is very poorly understood, but if you stick to natural foods, you have a better chance of eating healthy.
2. Capitalism's optimises food for profit, not health. This is why processed food exists, it's cheaper because it lasts longer, because cheap unpalatable ingredients can be made palatable, because throwing sugar onto everything makes it hyper palatable, which makes people over eat.
In fact that latter line of thinking made me change my mind about GM food, which I'm not fundamentally against as a concept, but the problem is the driving force behind the idea - The cost function is not human health, it's profit. This is problematic because it's possible to modify things for e.g greater yield but not necessarily for greater nutritional value, it could actually have the inverse relationship, over time this is going to work against you, it's inevitable. I also misunderstood GM to mean less need for harsh chemical pesticides, but it's all about intent again, the same people are usually trying to maximize yield so they will throw everything they can at the land.