Former frontend developer here -- I did fight with these misalignments (typically those things that don't align were lots of nested containers, fighting with each other in different ways, so the solution was to clean them up and use one simple alignment).

But I stopped noticing these things, maybe because mobile UIs are a lot worse -- not in visual design, but in that they always do weird things and live their own life.

Misalignment is a tiny dirty spot on a clean but wrecked car.