Skeuomorphic design, to me, largely feels lazy and unattractive; rather than designing for the new, maybe unfamiliar, medium you're working in, you attempt some facsimile which inevitably cannot live up to the original, either out of lack of ambition, or lack of faith in your audience to understand or appreciate without the anchor of a common metaphor. It lacks idiomaticity - there are particular details, quirks, associated with different mediums that lend themselves to different sorts of designs, and a skeuomorphic design language ignores these. (The same is true of musical instruments. A piece written for the lute, say, played on piano, would feel very different than a piece written for piano, played on piano; what is easy, or possible, on one instrument, is not necessarily as sonorous on another.)
To me, the use of synthesizers to emulate acoustic instruments, where the express intent of the composer/producer/whatever is to evoke the sound of that acoustic original (read: where the creator would prefer the sound of the real instrument), is, at its most generous, telling of a lack of creativity and at worst laziness. (If what you want is expressly the sound of a synthetic imitation for the purposes of your art, none of this applies.) It is a lack of creativity in the case where the creator simply does not have access to "real" instruments they'd rather use, and it's laziness where you have access and ability but opt for something you yourself deem inferior.
Of course, this all presupposes that there is something lost when say, a synthesizer plays a violin patch in an earnest effort by the creator to emulate a violin - where a real violin is actually what's desired. I think this isn't controversial to say, but of course it's a spectrum; I have much less of a problem in cases where the delta is smaller; e.g., simple legato harmonies from a string section can be emulated more convincingly (by orders of magnitude) than some virtuosic cadenza by a solo instrumentalist.