As a longtime observer of the scene, no. Creating the smallest board possible while maintaining original game compatibility are about the only metrics to stick to. Usually this boils down to keeping the CPU, GPU, NAND (if exists like the Wii), and most times the RAM.

There are some nuts people out there like Redherring32 with his TinyTendo project that go above and beyond just putting the components on a new board. He designed the TinyTendo which requires cutting down the DIP-packaged CPU and PPU from the NES into a smaller package. These components were only produced for Nintendo systems of the era and are the special sauce for overall game compatiblity. https://github.com/Redherring32/TinyTendo

Ship of Wiiseus