Some Javascript or maybe Canvas heavy pages run much more slowly on Firefox and are almost unusable on Firefox for Android. I find that this is rare, though.
I'll keep using Firefox + uBlock + Personal Blocklist + Dark Reader + Disable Javascript + Disable CSS + Tampermonkey + Old Reddit Redirect + CORS Everywhere + Consent-O-Matic + Hide YouTube Shorts + Load Reddit Images Directly + ...
Please cite some actual examples.
The only real exception I can think of is that Google Meet's audio quality has recently been worse under Firefox than under Safari's. My guess is that the issue is on Google's end (since Firefox used to be fine), or that maybe Safari has access to some special microphone APIs.
For example, the audio in FF outside of Apple sounds real clear and overall great in my experience.
Not even in the slightest.