I think by now most startups, YC or not, in Silicon Valley will pretty much have a similar setup:
1) Choose the main web-stack (Rails or Django)
2) Choose the API framework (node.js, or something else)
3) Memcached for caching (or some NoSQL)
4) A message queue (ZeroMQ, RabbitMQ, or something ...)
5) nginx, HAProxy, Varnish, (or similar technology)
6) Hadoop for map-reduce (only if you need to go that path...)