Too bad most people use Javascript frameworks for desktop development.
Not that I'm in favour of developing desktop applications in JavaScript or anything. I don't really think those are a great idea. It's just that there's a lot of intermediate steps between "let's use JavaScript" and "let's worry about using the best x86 opcodes" which are perhaps more sensible than either extreme.
Nobody writes desktop software in a GC'd language that doesn't suffer from noticeable performance issues. There's a reason why people bitch about e.g., Microsoft Teams, and it has a lot to do with language choice.
Programmers choose GC languages because it's what they want, not what users want.