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> Building an accessible canvas-based UI with a React-like API would make a lot more sense for SPAs

React is the Simpsons of web tech (Referring to the "Simpsons did it meme" if that wasn't clear).

Thanks this is really close to what I was imagining, but looks like it’s been inactive for a long time.

Yes, the reactions to it were not very enthusiastic as you'd expect. Also it did have a11y issues.

There are a lot of interesting renderers for react, some of them are even maintained: https://github.com/chentsulin/awesome-react-renderer