It's all just kind of f'd anyway.

The biological need for "water" is tuned to expect "water" to involve all sorts of trace minerals and compounds, some desired and some undesired, as well as some kind of stream of gut flora contributors and immune system challenges.

Thinking of RO and other forms of heavily or industrially purified H20 as the same thing is a technologist's mistaken idealization, and to a cynical eye reads a lot more like ancient Hellenic ideas about simple essential fluids than anything either scientific or sustainable.

It may be a necessary compromise because of modern contamination or because modern demand forces us to rely on increasingly worse supplies, but it's a long way from "verifying the response". It's more like an ugly last resort hack.