I saw a couple of years of similar reactions from my sisters after they went through some difficult times without any of us knowing (since they were studying abroad and this was before easy internet calling). They'd get mad when asked seemingly innocuous questions, which turned out to be because the way the questions were phrased came off as insulting or dismissive of their problems in some way. We didn't even know about these problems since they never told us, but that didn't really matter for them.
It took years of slowly rebuilding trust for them to open up again.