To this day 8x7b Mixtral remains the best model you can run on a single 48GB GPU. This has the potential to become the best model you can run on two such GPUs, or on an MBP with maxed out RAM, when 4-bit quantized.
Edit: To add to this, I've had good luck getting solid output out of mixtral 8x7b at 3-bit, so that isn't small enough to completely kill the model's quality.
https://github.com/ggerganov/llama.cpp?tab=readme-ov-file#qu...