Personally, BTRFS is the only filesystem that has ever caused me any data loss or downtime. I was using a single disk, so it should have been the perfect path. At some point the filesystem got into a state where the system would hang when mounting it read/write. I was able to boot off of a USB stick and recover my files, but I was unable to get the filesystem back into a state where it could be mounted read/write.
At work, we used to run BTRFS on our VMs as that was the default. Without fail, every VM would eventually get into a state where a regular maintenance process would completely hang the system and prevent it from doing whatever task it was supposed to be doing. Systems that wrote more to their BTRFS filesystems experienced this sooner than ones that didn't write very much, but eventually every VM succumbed to this. Eventually the server team had to rebuild every VM using ext4.
I know that anecdotes aren't data, but my experience with BTRFS will keep me from using it for anything even remotely important.