Seriously though, it's John's show and he's free to take it to another network. I just _really_ hope that this transition was done in a respectful manner and that there isn't bad blood between 5by5 and Mule.
A little background: Let's Make Mistakes, Mule Radio's main show, got started with 5by5's help. Let's Make Mistakes was a 5by5 network show for it's first year of existence. It garnered all of the listenership and cross promotion that comes with being part of 5by5. After a year of getting traction, Mule split the show off into its own podcasting network, essentially becoming a competitor to 5by5. If Mule now aggressively poached The Talk Show from 5by5 then it was certainly a dick move.
Of course, we don't have all the details and this is just speculation. So again, I hope this was done in a way that respected Dan and 5by5.